Liang Lab focuses on the following three research areas in bioinformatics

  1. Develop bioinformatics software tools
  2. Build and maintain biological databases
  3. Conduct data analysis and data mining to address interesting biological questions

Current Research Projects

  1. Determining repeatome loci as the potential biomarkers of the diagnosis, progression and theurapeutic targets in Osteosarcoma
  2. Genome-wide detection and functional characterization of DNA and RNA transposons
  3. In silico exploration of DNA repeats (e.g., tandem repeats, direct repeats, inverted repeats, and interspersed repeats) and their potential roles in gene expression regulation
  4. CRISPR-based DNA and RNA editing: target design and specificity
  5. Genome-wide detection of CRISPRs in prokaryotic genomes
  6. DNA methylation and its role in tissue regeneration
  7. RNA-Seq based transcriptome analysis and differentially expressed gene analysis
  8. Small non-coding RNAs (miRNAs, siRNAs and piRNAs) biogenesis and their differential expression analysis
  9. Genome-wide analysis of alternative polyadenylation and alternative splicing in eukaryotes